Potassium Hydroxide → HCID 86592890, compound

Participants

Reaction Steps

The title compound was prepared by the procedures described in Example 155, substituting the ethyl ester from Example 137 with ethyl ester from Example 337, and KOH with NaOH, to give a white solid. 1H NMR (d6-DMSO, 300 MHz) 3 1.29-1.45 (m, 1H), 1.45-1.78 (m, 2H), 1.78-2.02 (m, 1H), 2.20-2.40 (m, 1H), 2.82 (brt, J=10.5 Hz, 1H), 3.08 (brt, J=10.5 Hz, 1H), 3.80-4.07 (m, 2H), 3.86 (s, 3H), 4.384.50 (m, 1H), 6.42 (d, J=8.4 Hz, 1H), 6.54 (d, J=3.0 Hz, 1H), 7.19 (d, J=15.3 Hz, 1H), 7.32 (dd, J=1.8, 8.7 Hz, 1H), 7.48 (d, J=3.0 Hz, 1H), 7.64 (d, J=8.7 Hz, 1H), 7.67-7.77 (m, 2H), 7.87 (d, J=1.8 Hz, 1H). MS (ESI+) (M+H)+ at m/z 489,491,493. Anal. Calcd for C24H22Cl2N2O3S.0.56 CH2Cl2: C, 54.94; H, 4.34; N, 5.22. C, 54.89; H, 4.44; N, 5.32.

Provenance & Evidence