1-[2-(2-Hydroxyethoxy)ethyl]piperazine → HCID 20765601, compound

HRID 1815514Notes

Reaction equation

HRID 1815514 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][C:11]1[CH:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([NH:21][CH2:22][CH2:23]CN2CCCC2=O)=[O:20])=[C:13]([Cl:31])[C:12]=1[Cl:32])([CH3:3])[CH3:2].[OH:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][N:39]1CCN[CH2:41][CH2:40]1>>[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10][C:11]1[CH:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([N:21]2[CH2:22][CH2:23][N:39]([CH2:38][CH2:37][O:36][CH2:35][CH2:34][OH:33])[CH2:40][CH2:41]2)=[O:20])=[C:13]([Cl:31])[C:12]=1[Cl:32])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 1394361-[2-(2-Hydroxyethoxy)ethyl]piperazineHCID 87974482HCID 87974482, compound

Product 1

HCID 20765601HCID 20765601, compound

Procedure

The title compound was prepared from the cinnamide acid of Example 331, using the procedures described in Example 340 and substituting methyl isonipecotate with N-[2-(2-hydroxyethoxy)ethyl]piperazine. 1H NMR (300 MHz, DMSO-d6) δ 1.18 (d, 6H), 3.0 (m, 3H), 3.30 (m, 2H), 3.50 (m, 10H), 3.80 (m, 2H), 4.50 (t, 1H), 6.45 (d, 1H), 7.30 (d, 1H), 7.35 (dd, 1H), 7.55 (d, 1H), 7.60 (m, 2H), 7.75 (d, 1H), 7.80 (d, 1H). MS (ESI+) m/z 523 (M+H)+.

Sources & evidence

ORD record
ord-fa9a558863b14d0cbd7ea170fb8c6554
Source dataset
uspto-grants-2005_04
Patent number
US06878700B1

Reaction notes

Loading…