HCID 57211727, compound → HCID 57151220, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl (1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isobutylamino)propylcarbamate (0.5 g, 1.1 mmol) in anhydrous tetrahydrofuran (12 mL) was added 0.5 g of palladium (on charcoal, 10% Pd, Degussa type). The mixture was stirred under an atmospheric pressure of hydrogen for 12 hours. The catalyst was filtered and the solvent was removed under reduced pressure resulting in 0.4 g (98%) of the title compound. 1H-NMR (CDCl3): δ 0.92 (6H,dd), 1.35 (9H,s), 1.83 (1H,m), 2.44-2.55 (2H,m), 2.73-2.85 (4H,m), 3.49 (1H,m), 3.70-3.79 (1H,m,b), 4.66 (1H,d), 6.72 (2H,d), 7.05 (2H,d).

Provenance & Evidence