HCID 86591161, compound → 2-(2-Aminothiazole-4-yl)-2-acetoxyiminoacetic acid

HRID 1815599Notes

Reaction equation

HRID 1815599 reaction equation
O.O.[NH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][C:15](=[O:17])[CH3:16])[C:10]([OH:12])=[O:11])[N:8]=1>CC(C)=O>[NH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:13][O:14][C:15](=[O:17])[CH3:16])[C:10]([OH:12])=[O:11])[N:8]=1

Participants

3

Reactant 1

HCID 86591161HCID 86591161, compound

Product 1

HCID 533948252-(2-Aminothiazole-4-yl)-2-acetoxyiminoacetic acidYield 94.9%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
55.5 °C

Procedure

2-(2-aminothiazole-4-yl)-2-acetoxyiminoacetic acid dihydrate (syn-isomer) (20.0 g) was suspended in acetone (200 ml) and stirred, and heated and refluxed at 55 to 56° C. for one hour. After the mixture was cooled to 5° C., the crystal was filtered and washed with acetone, and dried under reduced pressure to obtain 2-(2-aminothiazole-4-yl)-2-acetoxyiminoacetic acid anhydrous crystal (16.4 g).

Workup

  1. temperatureheated
  2. temperatureAfter the mixture was cooled to 5° C.
  3. filtrationthe crystal was filtered
  4. washwashed with acetone
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-a927e5e1501c4518a076babb856a9699
Source dataset
uspto-grants-2005_04
Patent number
US06878827B2

Reaction notes

Loading…