Ammonia → HCID 86591162, compound

Participants

Reaction Conditions

Reaction Steps

4-chloro-2-(methoxycarbonylmethoxyimino)-3-oxobutyric acid (200 g) was added to water (400 ml), and suspended and stirred at 5° C. The crystal was dissolved by using sodium hydrogencarbonate (71.2 g). Thiourea (70.5 g) was added, and reaction was performed for 60 minutes at 30° C. while keeping the pH at 5.5 by using aqueous ammonia. After the pH was adjusted to 2 by using dilute hydrochloric acid, the mixture was cooled to 5° C. and stirred for 30 minutes. The precipitated crystal was filtered and collected, and washed with cold water, and then dried under reduced pressure to obtain 2-(2-aminothiazole-4-yl)-2-methoxycarbonylmethoxy iminoacetic acid monohydrate (syn-isomer) (225.2 g) (96.5% yield).

Provenance & Evidence