HCID 86591162, compound → HCID 53395232, compound

HRID 1815601Notes

Reaction equation

HRID 1815601 reaction equation
O.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[N:12][O:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]([OH:11])=[O:10])[N:7]=1>CC(C)=O>[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8](=[N:12][O:13][CH2:14][C:15]([O:17][CH3:18])=[O:16])[C:9]([OH:11])=[O:10])[N:7]=1

Participants

3

Reactant 1

HCID 86591162HCID 86591162, compound

Product 1

HCID 53395232HCID 53395232, compoundYield 96.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-(2-aminothiazole-4-yl)-2-methoxycarbonylmethoxyimino acetic acid monohydrate (syn-isomer) (10.0 g) was suspended and stirred in acetone (100 ml), and heated and refluxed for 120 minutes. The precipitated crystal was filtered and collected, and dried under reduced pressure to obtain anhydrous 2-(2-aminothiazole-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid (syn-isomer) (9.0 g) (96% yield).

Workup

  1. temperatureheated
  2. temperaturerefluxed for 120 minutes
  3. filtrationThe precipitated crystal was filtered
  4. customcollected
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-dc05dcd4b9674dff885fb0d7e6ee4066
Source dataset
uspto-grants-2005_04
Patent number
US06878827B2

Reaction notes

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