Phosphorus pentachloride → HCID 72739081, compound

Participants

Reaction Conditions

Reaction Steps

2-(2-aminothiazole-4-yl)-2-acetoxyiminoacetic acid anhydrous crystal (syn-isomer) (12.5 g) was suspended and stirred in methylene chloride (125 ml), and cooled to −20 to −25° C. Phosphorus pentachloride (13.6 g) was added thereto, and reaction was performed for 15 hours at the same temperature. The precipitated crystal was filtered, washed with methylene chloride, and dried under reduced pressure to obtain 2-(2-aminothiazole-4-yl)-2-acetoxyiminoacetyl chloride hydrochloride (syn-isomer) (14.6 g).

Provenance & Evidence