HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178511198, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | HCID 178419078 | HCID 178419078 | — |
| Reactant | D-Histidine | HCID 178511802 | — |
| Product | HCID 178511198 | HCID 178511198 | — |
Reaction Steps
An optical purity of >99.8% was determined for a sample obtained according to the procedure above. The determination was carried out by hydrolysing the amide bond (6 N hydrochloric acid, 110° C., 24 h), followed by derivatizing the liberated histidine with trifluoroacetic anhydride and isobutyl chloroformate. A D-histidine content of <0.1% was detected by means of gas chromatography on a chiral stationary phase.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06878829B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-d7c3bfc07a324e49a5b26646ad9eb182 |
| Source note | uspto-grants-2005_04 |