Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 1-Hexen-3-one | HCID 15395 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 10920798 | HCID 10920798 | — |
Reaction Steps
A solution of sodium methoxide in MeOH is added to a solution of 1-hexen-3-one and nitromethane in MeOH at −30° C. The reaction mixture is then warmed to −10° C. for 1.5 h, quenched with half saturated ammonium chloride solution, and then extracted with dichloromethane. The combined organics are dried over sodium sulfate concentrated and then stripped from toluene and MeOH to provide 7-nitro-heptan-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06878848B2 |
|---|
| Source dataset | uspto-grants-2005_04 |
|---|
| ORD ID | ord-a219cd28fdc44be58fb599bde2a8b232 |
|---|
| Source note | uspto-grants-2005_04 |
|---|
