1-Bromo-2-methylpropane → HCID 86591860, compound

HRID 1815707Notes

Reaction equation

HRID 1815707 reaction equation
[C:1]([NH:5][C:6](=[O:8])[OH:7])([CH3:4])([CH3:3])[CH3:2].COC[C:12]1([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]1.C(Br)C(C)C>>[CH:2]([C:12]1([S:15]([NH2:18])(=[O:17])=[O:16])[CH2:14][CH2:13]1)=[C:1]([CH3:4])[CH3:3].[C:1]([NH:5][C:6](=[O:7])[O-:8])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 667523821-Methoxymethylcyclopropylsulfonylamine tert-butylcarbamate

Product 1

HCID 86591860HCID 86591860, compound

Procedure

Step 44a) This compound, 1-(2-Methyl-allyl)-cyclopropanesulfonamide-tert-butylcarbamate, was obtained in 95% (1.18 g) from 1.0 g (4.52 mmol) of cyclopropanesulfonamide-tert-butylcarbamate according to the procedure described in the synthesis of 1-methoxymethylcyclo-propylsulfonylamine tert-butylcarbamate (Step 15IId) except 1.1 equivalents of iso-butyl bromide was used as electrophile: 1H NMR (CDCl3) □ ppm 0.93 (m, 2H), 1.49 (s, 9H), 1.73 (m, 2H), 1.78 (d, J=7.93 Hz, 3H), 2.58 (s, 2H), 4.87 (m, 1H), 4.88 (m, 1H), 6.77 (s, 1H).

Sources & evidence

ORD record
ord-a354e2874a4642b2baf7da8886543112
Source dataset
uspto-grants-2005_04
Patent number
US06878722B2

Reaction notes

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