4-(Trifluoromethyl)phenylboronic acid → 4-[5-(4-Trifluoromethyl-phenyl)-benzooxazol-2-YL]-1,4-diaza-bicyclo[3.2.2]nonane

HRID 1815771Notes

Reaction equation

HRID 1815771 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1.Br[C:15]1[CH:16]=[CH:17][C:18]2[O:22][C:21]([N:23]3[CH:29]4[CH2:30][CH2:31][N:26]([CH2:27][CH2:28]4)[CH2:25][CH2:24]3)=[N:20][C:19]=2[CH:32]=1>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([C:15]2[CH:16]=[CH:17][C:18]3[O:22][C:21]([N:23]4[CH:29]5[CH2:28][CH2:27][N:26]([CH2:31][CH2:30]5)[CH2:25][CH2:24]4)=[N:20][C:19]=3[CH:32]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 224957824-(5-Bromobenzoxazol-2-yl)-1,4-diazabicyclo[3.2.2]nonane

Product 1

HCID 224957814-[5-(4-Trifluoromethyl-phenyl)-benzooxazol-2-YL]-1,4-diaza-bicyclo[3.2.2]nonaneYield 54%

Procedure

The title compound was prepared according to the procedure in Example 44 using 4-trifluoromethyl-phenylboronic acid and 4-(5-bromo-benzooxazol-2-yl)-1,4-diaza-bicyclo[3.2.2]nonane in 54% yield: MS (Cl) m/z 388.4 (M+1).

Sources & evidence

ORD record
ord-4cc6cb69cbbe42be9f989fc955284387
Source dataset
uspto-grants-2005_04
Patent number
US06881734B2

Reaction notes

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