2-Bromo-4,5-difluorophenol → 7-Bromo-4,5-difluorobenzofuran

HRID 1815796Notes

Reaction equation

HRID 1815796 reaction equation
BrC1C=C(F)C(F)=CC=1O.C(O[CH:14](OCC)[CH2:15][O:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([F:24])=[CH:19][C:18]=1[Br:25])C>>[F:23][C:21]1[C:22]2[CH:14]=[CH:15][O:16][C:17]=2[C:18]([Br:25])=[CH:19][C:20]=1[F:24]

Participants

3

Reactant 2

HCID 27362882-Bromo-4,5-difluorophenolHCID 221448552-(2-Bromo-4,5-difluorophenoxy)-acetaldehyde diethyl acetal

Product 1

HCID 221448747-Bromo-4,5-difluorobenzofuran

Procedure

Beginning with 5 gm (23.9 mMol) 2-bromo-4,5-difluorophenol, 7.05 gm (91%) 2-(2-bromo-4,5-difluorophenoxy)acetaldehyde diethyl acetal were prepared essentially as described in Preparation IV.

Workup

  1. customwere prepared essentially

Sources & evidence

ORD record
ord-302c2582056e44a197559339507879f8
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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