Sulfuric Acid → HCID 22144913, compound

HRID 1815814Notes

Reaction equation

HRID 1815814 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([F:10])[C:7]([Br:11])=[CH:6][C:5]=1[OH:12])[CH:2]=C.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[F:10][C:8]1[C:7]([Br:11])=[CH:6][C:5]2[O:12][CH:2]=[CH:1][C:4]=2[CH:9]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 22144936HCID 22144936, compound

Product 1

HCID 22144913HCID 22144913, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Beginning with 3.5 gm (15 mMol) 2-allyl-4-fluoro-5-bromophenol, the title compound was prepared in 90% yield essentially by the procedure described in Preparation XXXI with the exception that the cyclization/dehydration step was performed using sulfuric acid in toluene.

Sources & evidence

ORD record
ord-b214cb630a8848528f04998e75000d95
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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