反应详情

A mixture of 23.4 gm (89.7 mMol) methyl 1-benzyl-2,4-dioxo-3-piperidinecarboxylate in 200 mL 10% aqueous oxalic acid was stirred at reflux for 15 hours. The reaction mixture was cooled to room temperature and the solution extracted with 3×200 mL dichloromethane. The organic phases were combined, dried over magnesium sulfate, and concentrated under reduced pressure to provide 4.99 gm (27%) of the desired compound.

1. temperatureat reflux for 15 hours
2. extractionthe solution extracted with 3×200 mL dichloromethane
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated under reduced pressure