1-Benzyl-3,3-dimethylpiperidin-4-one → HCID 22495635, compound

HRID 1815842Notes

Reaction equation

HRID 1815842 reaction equation
[F:1][C:2]1[CH:3]=[C:4](Br)[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[C:21]([CH3:27])([CH3:26])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:25])([C:4]2[C:5]3[O:9][CH:8]=[CH:7][C:6]=3[CH:10]=[C:2]([F:1])[CH:3]=2)[C:21]([CH3:27])([CH3:26])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 97944131-Benzyl-3,3-dimethylpiperidin-4-oneHCID 221448167-Bromo-5-fluoro-1-benzofuran

Product 1

HCID 22495635HCID 22495635, compoundYield 546.6%

Procedure

Beginning with 0.28 gm (1.32 mMol) 5-fluoro-7-bromobenzofuran and 0.19 gm (0.088 mMol) 1-benzyl-3,3-dimethyl-4-oxo-piperidine, 0.17 gm (53%) of the desired compound were prepared essentially as described in EXAMPLE 3.

Sources & evidence

ORD record
ord-f3287c9559ef49afa84b2530e3426d08
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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