HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-methyl-4-piperidone → 1-Benzyl-3-methyl-4-hydroxy-4-(4-trifluoromethylbenzofur-7-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-methyl-4-piperidone | HCID 560965 | — |
| Reactant | 7-Bromo-4-(trifluoromethyl)benzofuran | HCID 12114707 | — |
| Product | 1-Benzyl-3-methyl-4-hydroxy-4-(4-trifluoromethylbenzofur-7-yl)piperidine | HCID 22495638 | 39% |
Reaction Steps
Beginning with 1.5 gm (5.7 mMol) 4-trifluoromethyl-7-bromobenzofuran and 1.26 gm (6.2 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 0.85 gm (39%) of the desired compound were recovered essentially as described in EXAMPLE 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06881733B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-1ebd5c319411477793b384f19d33e89f |
| Source note | uspto-grants-2005_04 |