HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-methyl-4-piperidone → 1-Benzyl-3-methyl-4-hydroxy-4-(5-trifluoromethylbenzofur-7-yl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-methyl-4-piperidone | HCID 560965 | — |
| Reactant | 5-Trifluoromethyl-7-bromobenzofuran | HCID 22144871 | — |
| Product | 1-Benzyl-3-methyl-4-hydroxy-4-(5-trifluoromethylbenzofur-7-yl)piperidine | HCID 22495755 | 43.3% |
Reaction Steps
Beginning with 1.1 gm (4.15 mMol) 5-trifluoromethyl-7-bromobenzofuran and 0.93 gm (4.57 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 0.70 gm (43%) of the desired compound were recovered as a yellow solid essentially as described in EXAMPLE 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06881733B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-ad47722e5c0e4315a779772a0c2e4c45 |
| Source note | uspto-grants-2005_04 |