1-Benzyl-3-methyl-4-piperidone → 1-Benzyl-3-methyl-4-hydroxy-4-(4,5-difluorobenzofur-7-yl)piperidine

HRID 1815851Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1815851
[F:1][C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[C:5](Br)=[CH:4][C:3]=1[F:12].[CH2:13]([N:20]1[CH2:25][CH2:24][C:23](=[O:26])[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([OH:26])([C:5]2[C:6]3[O:10][CH:9]=[CH:8][C:7]=3[C:2]([F:1])=[C:3]([F:12])[CH:4]=2)[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Komponenten

3

Edukt 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 221448747-Bromo-4,5-difluorobenzofuran

Produkt 1

HCID 224956641-Benzyl-3-methyl-4-hydroxy-4-(4,5-difluorobenzofur-7-yl)piperidineAusbeute 43 %

Versuchsvorschrift

Beginning with 4.0 gm (17.17 mMol) 4,5-difluoro-7-bromobenzofuran and 3.8 gm (18.88 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 2.6 gm (43%) of the desired compound were recovered as a yellow oil essentially as described in EXAMPLE 3.

Quellen und Nachweise

ORD-Eintrag
ord-37eded14cecc45249f79aee254a296ee
Quelldatensatz
uspto-grants-2005_04
Patentnummer
US06881733B1

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