HCID 22495608, compound → HCID 69744956, compound

HRID 1815855Notes

Reaction equation

HRID 1815855 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[C:17]([Cl:23])=[C:16]([F:24])[CH:15]=2)[CH:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C(Cl)=C(F)C=2)C(C)C1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[C:17]([Cl:23])=[C:16]([F:24])[CH:15]=2)[C@H:10]([CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 22495608HCID 22495608, compoundHCID 22495713HCID 22495713, compound

Product 1

HCID 69744956HCID 69744956, compound

Procedure

Beginning with 0.56 gm (1.49 mMol) 1-benzyl-3-methyl-4-hydroxy-4-(4-chloro-5-fluorobenzofur-7-yl)piperidine, 1-benzyl-3-methyl-4-(methyl oxoacetoxy)-4-(4-chloro-5-fluorobenzofur-7-yl)piperidine was recovered essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide the desired compound.

Workup

  1. customwas recovered essentially
  2. additionThis material was treated with tri(n-butyl)tin hydride essentially

Sources & evidence

ORD record
ord-852d458e5da0404fb3b32ff5c0883154
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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