HCID 22495688, compound → HCID 69744908, compound

HRID 1815856Notes

Reaction equation

HRID 1815856 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](O)([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[CH:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N1CCC(OC(=O)C(C)=O)(C2C3OC=CC=3C=CC=2F)C(CC)C1)C1C=CC=CC=1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[C:22]3[O:21][CH:20]=[CH:19][C:18]=3[CH:17]=[CH:16][C:15]=2[F:23])[C@H:10]([CH2:25][CH3:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 22495688HCID 22495688, compoundHCID 22495710HCID 22495710, compound

Product 1

HCID 69744908HCID 69744908, compoundYield 95.1%

Procedure

Beginning with 5.4 gm (15.3 mMol) 1-benzyl-3-ethyl-4-hydroxy-4-(6-fluorobenzofur-7-yl)piperidine, 5.91 gm (88%) 1-benzyl-3-ethyl-4-(methyl oxoacetoxy)-4-(6-fluorobenzofur-7-yl)piperidine was recovered as an orange oil, essentially as described in EXAMPLE 16. This material was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to provide 4.91 gm of the desired compound.

Workup

  1. customwas recovered as an orange oil
  2. additionThis material was treated with tri(n-butyl)tin hydride essentially

Sources & evidence

ORD record
ord-9bf9289dffec4f1ea2a8aee263834dc3
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

Loading…