1-Benzyl-3-methyl-4-piperidone → HCID 22495572, compound

HRID 1815860Notes

Reaction equation

HRID 1815860 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]2[CH:6]=[CH:7][O:8][C:4]=2[C:3]=1Br.[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:25])([C:3]2[C:4]3[O:8][CH:7]=[CH:6][C:5]=3[CH:9]=[CH:10][C:2]=2[F:1])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 221449297-Bromo-6-fluoro-1-benzofuran

Product 1

HCID 22495572HCID 22495572, compoundYield 89.9%

Procedure

Beginning with 12.7 gm (59 mMol) 6-fluoro-7-bromobenzofuran and 13.2 gm (65 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 18 gm of the desired compound was prepared as an orange oil essentially as described in EXAMPLE 19.

Sources & evidence

ORD record
ord-52f8218739dc4e049dba7d562ba96309
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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