1-Benzyl-3-methyl-4-piperidone → 1-Benzyl-3-methyl-4-hydroxy-4-(benzofur-4-yl)piperidine

HRID 1815861Notes

Reaction equation

HRID 1815861 reaction equation
Br[C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH2:11]([N:18]1[CH2:23][CH2:22][C:21](=[O:24])[CH:20]([CH3:25])[CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([N:18]1[CH2:23][CH2:22][C:21]([OH:24])([C:2]2[C:7]3[CH:8]=[CH:9][O:10][C:6]=3[CH:5]=[CH:4][CH:3]=2)[CH:20]([CH3:25])[CH2:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 151587214-Bromo-1-benzofuran

Product 1

HCID 224955341-Benzyl-3-methyl-4-hydroxy-4-(benzofur-4-yl)piperidineYield 69%

Procedure

Beginning with 2.0 gm (10.2 mMol) 4-bromobenzofuran and 2.06 gm (10.2 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 2.24 gm (69%) of the desired compound were prepared essentially as described in EXAMPLE 19.

Sources & evidence

ORD record
ord-bf758aa892ce4efdac21bb8022648550
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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