1-Benzyl-3-methyl-4-piperidone → HCID 22495776, compound

HRID 1815864Notes

Reaction equation

HRID 1815864 reaction equation
Br[C:2]1[C:7]2[CH:8]=[CH:9][O:10][C:6]=2[CH:5]=[CH:4][C:3]=1[F:11].[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([OH:25])([C:2]2[C:7]3[CH:8]=[CH:9][O:10][C:6]=3[CH:5]=[CH:4][C:3]=2[F:11])[CH:21]([CH3:26])[CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 22144695HCID 22144695, compound

Product 1

HCID 22495776HCID 22495776, compoundYield 68%

Procedure

Beginning with 1.13 gm (5.26 mMol) 4-bromo-5-fluorobenzofuran and 1.18 gm (6.2 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 1.21 gm (68%) of the desired compound were prepared essentially as described in EXAMPLE 19.

Sources & evidence

ORD record
ord-de07915381b9444ca47f35efbe1eb8f7
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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