Tributylstannane → HCID 22495705, compound

Participants

Reaction Steps

Beginning with 0.84 gm (2.26 mMol) 1-benzyl-3,3-dimethyl-4-hydroxy-4-(4,6-difluorobenzofur-7-yl)piperidine, 0.84 gm (81%) 1-benzyl-3,3-dimethyl-4-(methyl oxoacetoxy)-4-(4,6-difluorobenzofur-7-yl)piperidine were prepared essentially as described in EXAMPLE 16. This material (0.57 gm, 1.25 mMol) was treated with tri(n-butyl)tin hydride essentially as described in EXAMPLE 16 to prepare 0.35 gm (79%) of the desired compound.

Provenance & Evidence