1-Benzyl-3-methyl-4-piperidone → HCID 22495727, compound

HRID 1815868Notes

Reaction equation

HRID 1815868 reaction equation
[F:1][C:2]1[C:3]([F:12])=[C:4](Br)[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][C:23](=[O:26])[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([OH:26])([C:4]2[C:5]3[O:9][CH:8]=[CH:7][C:6]=3[CH:10]=[C:2]([F:1])[C:3]=2[F:12])[CH:22]([CH3:27])[CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 5609651-Benzyl-3-methyl-4-piperidoneHCID 22277250HCID 22277250, compound

Product 1

HCID 22495727HCID 22495727, compoundYield 38.7%

Procedure

Beginning with 0.22 gm (0.94 mMol) 5,6-difluoro-7-bromobenzofuran and 0.21 gm (1.04 mMol) 1-benzyl-3-methyl-4-oxopiperidine, 0.13 gm (38%) of the desired compound were prepared essentially as described in EXAMPLE 19.

Sources & evidence

ORD record
ord-3b47d2a8893040a29eeaae1ac96a50b1
Source dataset
uspto-grants-2005_04
Patent number
US06881733B1

Reaction notes

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