HCID 23536229, compound → HCID 22496108, compound

Participants

Reaction Steps

{3-[4-(3-Bromo-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl)-acetic acid methyl ester (142 mg, 0.3425 mmol) was dissolved in THF (34.5 ml) and 1N LiOH/water (6.85 ml). The reaction was stirred vigorously at RT for 2 h. The organic solvent was evaporated off. The aqueous solution was acidified to pH 3 with 1N HCl, whereupon a white precipitate formed. The precipitate was filtered and dried under vacuum, giving {3-[4-(3-bromo-phenylamino)-[1,3, 5]triazin-2-ylamino]-phenyl}-acetic acid. MS m/z 401=[M+H]+. Calc'd for C17H14BrN5O2: 399.03.

Provenance & Evidence