1-Benzyl-5-nitro-1H-indazole → 1-(Phenylmethyl)-1H-indazol-5-amine

Participants

Reaction Steps

To 906.4 mg (3.58 mmol) of 1-benzyl-5-nitro-1H-indazole (Step 1) in 20 mL of MeOH and 5 mL of EtOAc at RT was added a slurry of 150 mg of 10% Pd—C in 5 mL of MeOH. The resulting slurry was then stirred under a balloon of H2 for 1.2 h, filtered through Celite®, and rinsed with MeOH and EtOAc. Concentration of the filtrate gave (1-benzyl-1H-indazol-5-yl)amine as a pinkish solid: MS m/z=224 [M+H]+. Calc'd for C14H13N3: 223.11.

Provenance & Evidence