5-nitro-1-(pyridin-2-ylmethyl)-1H-indazole → 1-(Pyridin-2-ylmethyl)-1H-indazol-5-amine

Participants

Reaction Steps

To 5-nitro-1-pyridin-2-ylmethyl-1H-indazole (Step 1) (671 mg, 2.63 mmol) in MeOH (15 mL) and EtOAc (5 mL) at RT was added a slurry of 10% Pd/C (150 mg) in MeOH (5 mL). The resulting slurry was stirred under a balloon of H2 for 1.75 h, filtered through Celite®, and rinsed with MeOH and EtOAc. Concentration of the filtrate gave 1-pyridin-2-ylmethyl-1H-indazol-5-ylamine.

Provenance & Evidence