Diisopropylethylamine → HCID 10271171, compound

Participants

Reaction Conditions

Reaction Steps

To a slurry of N-methyl-2-chloro-4-(3-chloroanilino)-1,3,5-triazine (Step 1) (44.6 mg, 0.175 mmol) in IpOH (2.0 ml) was added DIEA (0.046 mL, 0.26 mmol) and N-(3-aminophenyl)acrylamide (31 mg, 0.192 mmol). The mix was heated at 100° C. for 18 h. The solution was then cooled to RT. The organics were concentrated under reduced pressure and the crude product was purified via column chromatography (elution with EtOAc) to give N-(3-{4-[(3-chlorophenyl)-methyl-amino]-[1,3,5]triazin-2-ylamino}-phenyl)-acrylamide: MS m/z=381 [M+H]+. Calc'd for C19H17ClN6O: 380.12.

Provenance & Evidence