Potassium Carbonate → HCID 22496109、化合物

関与物質

反応条件

反応手順

A mixture of the compound 2,4-dichloro-1,3,5-triazine (1.0 g, 5.97 mmol) and solid K2CO3 (4.0 g, 29 mmol) was suspended in AcCN (20 mL) under nitrogen at 0° C., followed by slow addition of 7-chloro-1,2,3,4-tetrahydro-quinoline (Step 1) (1.1 g, 6.56 mmol) as a solution in AcCN (20 mL) over 15 min. The mixture was stirred at 0° C. for 1 h. The solids were removed by suction filtration and washed with AcCN. The organics were concentrated under reduced pressure and the crude compound was purified via column chromatography to give 7-chloro-1-(4-chloro-[1,3,5]triazin-2-yl)-1,2,3,4-tetrahydro-quinoline).

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