Hydrochloric Acid → HCID 9844503, compound

Participants

Reaction Steps

To a solution of methyl (±)-[4-[4-[2-(6-methylaminopyridin-2-yl)-1-ethoxy]phenyl]-3-(5-methylthiazol-2-yl)butanoate (0.85 mmole) in 1:1 THF/H2O (5 mL) was added 1.0 N NaOH (1.28 mL, 1.28 mmole). After 18 hr the mixture was acidified to pH 6 using 10% HCl then concentrated to dryness. The residue was chromatographed on silica gel (EtOH) to give the title compound as a yellow solid (217 mg, 62% over 2 steps). MS (ES) m/e 412 (M+H)+. Anal. Calcd for C22H25N3O3S 1.2H2O: C, 61.01; H. 6.38; N. 9.70. Found: C, 61.25; H. 6.06; N, 9.32.

Provenance & Evidence