Acetonitrile → HCID 9888392, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-[3-(4-piperidinyl)-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-4-one (4 g, 12.8 mmol), acetonitrile (26 mL), water (1.4 mL), potassium carbonate (2.3 g, 16.6 mmol) and 3-fluorobenzyl chloride (1.55 mL, 12.8 mmol) was stirred at about 50 to 55° C. After cooling, water (84 mL) was added dropwise thereto. The mixture was stirred at room temperature for about 1 hour. Precipitated crystals were separated, washed with water (80 mL) and dried to obtain 5.09 g (yield 95%) of the desired compound as crystals.

Provenance & Evidence