Sodium Hydroxide → HCID 10053886, compound

HRID 1816173Notes

Reaction equation

HRID 1816173 reaction equation
C[O:2][C:3](=[O:40])[CH2:4][CH2:5][NH:6][C:7](=[O:39])[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][N:15]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)[C:16]2[S:17][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)[N:20]=2)=[CH:10][CH:9]=1.[OH-].[Na+]>C(O)C>[Cl:38][C:35]1[CH:34]=[CH:33][C:32]([N:15]([CH2:14][C:11]2[CH:10]=[CH:9][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:40])=[O:2])=[O:39])=[CH:13][CH:12]=2)[C:16]2[S:17][CH:18]=[C:19]([C:21]3[CH:22]=[CH:23][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:25][CH:26]=3)[N:20]=2)=[CH:37][CH:36]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 42637860HCID 42637860, compound

Product 1

HCID 10053886HCID 10053886, compoundYield 43.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-[4-({(4-Chlorophenyl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic acid methyl ester (18.7 g, 31.7 mmol) was dissolved in ethanol (500 mL) and 1 N sodium hydroxide (63 mL, 63 mmol) was added. The resulting mixture was stirred at room temperature for 16 hours. The mixture was filtered, washed with ethanol and dried in vacuo at 40° C. for 16 hours to afford 8.0 g (42%) of the title compound as the sodium salt.

Workup

  1. filtrationThe mixture was filtered
  2. washwashed with ethanol
  3. customdried in vacuo at 40° C. for 16 hours

Sources & evidence

ORD record
ord-7680ca06b23a49f4924fa98fe923ce8a
Source dataset
uspto-grants-2005_04
Patent number
US06881746B2

Reaction notes

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