Potassium Carbonate → 2-Amino-6-methyl-4-[3-(3-methylphenyl)-1-cyclobutyl-1-propylamino]-1,3,5-triazine

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Reaction Steps

2.2 g (0.015 mol) of 2-amino-4-chloro-methyl-1,3,5-triazine and 4.1 g (0.03 mol) of K2CO3 are introduced into 50 ml of acetonitrile. 2.5 g (0.015 mol) of 3-(3-methylphenyl)-1-cyclobutyl-1-propylamine, dissolved in 20 ml of acetonitrile, are added dropwise to this solution. The mixture is then refluxed for 3 hours. The solid constituents are subsequently filtered off with suction and the filtrate is evaporated on a rotary evaporator. The residue is purified by means of column chromatography (eluant: ethyl acetate). This gives 4.3 g (92% of theory) of 2-amino-6-methyl-4-[3-(3-methylphenyl)-1-cyclobutyl-1-propylamino]-1,3,5-triazine.

Provenance & Evidence