Methyl iodide → 4-Fluoro-2-(methylsulfanyl)aniline

HRID 1816237Notes

Reaction equation

[CH2:1]([S:3][C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])C.NC1C=CC([F:18])=CC=1S.CI>>[CH3:1][S:3][C:4]1[CH:10]=[C:9]([F:18])[CH:8]=[CH:7][C:5]=1[NH2:6]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 3205472-Amino-5-fluorobenzene-1-thiol

HCID 101490092-(Ethylthio)aniline

Product 1

HCID 110948854-Fluoro-2-(methylsulfanyl)aniline

Procedure

Under conditions similar to those used for the preparation of 2-(ethylthio)aniline in Example 2, 2-amino-5-fluorothiophenol was alkylated with methyl iodide to give 2-methylthio-4-fluoroaniline.

Sources & evidence

ORD record: ord-91843986a71a4c2aa59fc06b96e7840b
Source dataset: uspto-grants-2005_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06884801B1

Reaction notes

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