Isatoic Anhydride → HCID 22493421, compound

HRID 1816258Notes

Reaction equation

HRID 1816258 reaction equation
[NH2:1][C:2]1[CH:17]=[CH:16][CH:15]=[CH:14][C:3]=1[C:4]([N:6]([CH2:10][CH:11]1[CH2:13][CH2:12]1)[CH2:7][CH2:8][CH3:9])=[O:5].[CH2:18]([NH:21][CH2:22][CH:23]1CC1)[CH2:19]C.C12C(=CC=CC=1)[NH:31]C(=O)OC2=O>>[CH:11]1([CH2:10][N:6]([CH2:7][CH2:8][CH3:9])[C:4](=[O:5])[C:3]2[CH:14]=[CH:15][CH:16]=[CH:17][C:2]=2[NH:1][CH2:23][C:22]2[NH:31][CH2:19][CH2:18][N:21]=2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 8359Isatoic AnhydrideHCID 117787Cyclopropanemethanamine, N-propyl-HCID 22493330HCID 22493330, compound

Product 1

HCID 22493421HCID 22493421, compound

Procedure

2-Amino-N-(cyclopropylmethyl)-N-propylbenzamide (prepared from N-propylcyclopropanemethylamine and isatoic anhydride, using the methods described in Example 17) and CMI were reacted using conditions described in the general procedure for CMI coupling to give N-(cyclopropylmethyl)-2-[(4,5-dihydro-1H-imidazol-2-ylmethyl)amino]-N-propylbenzamide.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-aab0120346534e86a42bfa4d44193229
Source dataset
uspto-grants-2005_04
Patent number
US06884801B1

Reaction notes

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