HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-piperidinyl) aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-pyrrolidinyl)aniline | HCID 22493417 | — |
| Product | N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-piperidinyl) aniline | HCID 22493274 | — |
Reaction Steps
Under conditions similar to those used for the preparation of N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-pyrrolidinyl)aniline (Example 64), piperidine was reacted with 2-fluoronitrobenzene, the nitro group was reduced, and the aniline was coupled, with CMI to give N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-(1-piperidinyl) aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884801B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-4b0c1b3487f14506858fa7a637303b74 |
| Source note | uspto-grants-2005_04 |