2-Bromo-3-methylpyridine → HCID 22493253, compound

Participants

Reaction Steps

2-Bromo-3-methylpyridine (0.65 g, 3.8 mmol) and N-(tert-butoxycarbonyl)-2-amino-1-phenylboronic acid (0.90 g, 3.8 mmol), prepared according to the method described by J. J. S. Lambda and J. M. Tour in J. Am. Chem. SDC., 1994,116,11723-11736, were coupled as in Example 70 (also see J. Org. Chem., 1995, 60, 292), to give 1.43 g of crude tert-butyl 2-(3-methyl-2-pyridinyl)phenylcarbamate, which was deprotected as in Example 75 to give 0.45 g of 2-(3-methyl-2-pyridinyl)aniline.

Provenance & Evidence