HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → HCID 22493241, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | HCID 292656 | HCID 292656 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22493241 | HCID 22493241 | — |
| Product | 1-Methyl-3-(2-nitrophenyl)-1H-pyrazole | HCID 22493249 | — |
Reaction Steps
3-(Dimethylamino)-2′-nitroacrylophenone (3.0 g, 13.5 mmol) in absolute ethanol (25 mL) was treated with methylhydrazine (800 μL, 20 mmol) and heated to reflux for 5 hours. The solvent was distilled off, and the residue chromatographed on silica eluting with 2:1 hexane:ethyl acetate to provide 1-methyl-5-(2-nitrophenyl)pyrazole (1.9 g) and 1-methyl-3-(2-nitrophenyl)pyrazole (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884801B1 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-0d9a425be9134d0893782c655ba9adfe |
| Source note | uspto-grants-2005_04 |