1,4-Dioxaspiro[4.5]decan-8-one → 1,4-Dioxaspiro(4.5)decan-8-ol

Participants

Reaction Steps

To a solution of 1,4-dioxaspiro[4,5]decan-8-one (96.9 g) in methanol (1 l) was added portionwise sodium borohydride (46.9 g) under ice-cooling. After stirring for 3.5 hours under ice cooling, the reaction mixture was successively stirred for 3 hours at room temperature. Then the solvent was evaporated in vacuo and the residue was purified by column chromatography on silica gel eluting with a mixture of hexane and ethyl acetate (1:1). The eluted fractions containing the desired product were collected and evaporated in vacuo to give 1,4-dioxaspiro-[4,5]decan-8-ol (97.9 g).

Provenance & Evidence