1-Heptanol, 7-bromo- → 7-Methoxy-1-heptanol

Temperature

90 °C

A mixture of 7-bromo-1-heptanol (25 g) and sodiummethoxide, 28% solution in methanol (37 ml) in methanol (250 ml) was stirred for 7 hours at 90° C. After being cooled to room temperature, the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture of dichloromethane and methanol (100:1→25:1). The eluted fractions containing the desired product were collected and evaporated in vacuo to give 7-methoxy-1-heptanol (18.2 g).

1. temperatureAfter being cooled to room temperature
2. customthe solvent was evaporated in vacuo
3. customThe residue was purified by column chromatography on silica gel eluting with a mixture of dichloromethane and methanol (100:1→25:1)
4. additionThe eluted fractions containing the desired product
5. customwere collected
6. customevaporated in vacuo

ORD record

ord-41df16ddb50f4e7a9756bd2ed6a28400

Source dataset

uspto-grants-2005_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06884774B2