4-Methoxypiperidine → 4-{4-[3-(4-Methoxy-piperidin-1-ylmethyl)-phenyl]-but-3-ynyl}-morpholine

HRID 1816369Notes

Reaction equation

HRID 1816369 reaction equation
[N:1]1([CH2:7][CH2:8][C:9]#[C:10][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[CH:14]=O)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:19][O:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:19][O:20][CH:21]1[CH2:26][CH2:25][N:24]([CH2:14][C:13]2[CH:12]=[C:11]([C:10]#[C:9][CH2:8][CH2:7][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[CH:18]=[CH:17][CH:16]=2)[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 776664-MethoxypiperidineHCID 224934723-(4-Morpholin-4-yl-but-1-ynyl)-benzaldehyde

Product 1

HCID 101721824-{4-[3-(4-Methoxy-piperidin-1-ylmethyl)-phenyl]-but-3-ynyl}-morpholine

Procedure

May be prepared analogously to Example 15 using the product of Example 10 and 4-methoxypiperidine.

Sources & evidence

ORD record
ord-7f0c6ce6e62443a99e6c26c8b5f91d58
Source dataset
uspto-grants-2005_04
Patent number
US06884803B2

Reaction notes

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