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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1816376Generated: November 1, 2026

Methyl 2-(bromomethyl)-6-methylbenzoate → Rac-cis-2-[3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]cyclohexylmethoxymethyl]-6-methylbenzoic acid

https://huagongshe.com/reaction/1816376

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(bromomethyl)-6-methylbenzoateHCID 10263795—
Reactantrel-(1R,3S)-3-HydroxycyclohexanemethanolHCID 15727328—
Reactant2-(4-Fluorophenyl)-4-(iodomethyl)oxazoleHCID 21980298—
ProductRac-cis-2-[3-[2-(4-fluorophenyl)oxazol-4-ylmethoxy]cyclohexylmethoxymethyl]-6-methylbenzoic acidHCID 131724079—

Reaction Steps

Reacting cis-3-hydroxymethylcyclohexanol, bromide 4 and iodide 2 in a reverse order relative to Example XXIV gave the product 41 of molecular weight 453.52 (C26H28FNO5); MS(ESI): 454 (M+H+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06884812B2
Source datasetuspto-grants-2005_04
ORD IDord-3f06e184dee8440699c38d0c2bb12c5f
Source noteuspto-grants-2005_04