4-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-7-amino-2-methyl-2,3-dihydro-1H-isoindol-1-one → diethyl (4-{[4-({7-[trans-4-(4-acetylpiperazin-1-yl)cyclohexyl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
Reaction equation
[C:30]([CH3:31])(=[O:32])[N:33]1[CH2:34][CH2:35][N:36]([CH:39]2[CH2:40][CH2:41][CH:42]([c:45]3[c:46]4[c:50]([c:51]([NH2:54])[cH:52][cH:53]3)[C:49](=[O:55])[N:48]([CH3:56])[CH2:47]4)[CH2:43][CH2:44]2)[CH2:37][CH2:38]1.[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH2:9][c:10]1[cH:11][c:12]([O:28][CH3:29])[c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[c:21]([Cl:23])[n:22]2)[cH:14][cH:15]1>>[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH2:9][c:10]1[cH:11][c:12]([O:28][CH3:29])[c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:24]([F:25])([F:26])[F:27])[c:21]([NH:54][c:51]3[c:50]4[c:46]([c:45]([CH:42]5[CH2:41][CH2:40][CH:39]([N:36]6[CH2:35][CH2:34][N:33]([C:30]([CH3:31])=[O:32])[CH2:38][CH2:37]6)[CH2:44][CH2:43]5)[cH:53][cH:52]3)[CH2:47][N:48]([CH3:56])[C:49]4=[O:55])[n:22]2)[cH:14][cH:15]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-db54c96d21e84fc0baaf4e5ac9ee40ce
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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