Acetone → HCID 86594541, compound

Participants

Reaction Steps

Following General Procedure A and using (2E,4E,6Z)-8,8,8-trifluoro-7-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-3-methyl-octa-2,4,6-trienoic acid ethyl ester (Intermediate 5, 160 mg, 0.37 mmol), K2CO3 (253 mg, 1.83 mmol), EtI (0.15 mL, 1.83 mmol), and acetone (2 mL) followed by HPLC (2.5% EtOAc-hexane), the title compound was obtained as a clear syrup (81 mg, 48%).

Provenance & Evidence