Ethanol → HCID 22493858, compound

Participants

Reaction Steps

Following General Procedure B and using (2E,4E,6Z)-8,8,8-trifluoro-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydro-naphthalen-2-yl)-octa-2,4,6-trienoic acid ethyl ester (Compound 3, 83 mg, 0.17 mmol), 1M NaOH (0.35 mL), and EtOH (3 mL) at 60° C. for 1.5 h followed by flash column chromatography on silica gel (30% EtOAc-hexane) and HPLC (15% EtOAc-hexane), the title compound was obtained as a white solid (60 mg, 77%).

Provenance & Evidence