HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride → 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-aldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Tris(hydroxymethyl)aminomethane | HCID 6503 | — |
| Reactant | 4,4-Dimethyl-5alpha-chola-8,14-dien-3beta,24-diol | HCID 15543092 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3beta-Hydroxy-4,4-dimethyl-5alpha-chola-8,14-dien-24-aldehyde | HCID 15543094 | 61.8% |
Reaction Steps
4,4-Dimethyl-5α-chola-8,14-dien-3β,24-diol (0.21 g) is dissolved in benzene (21 ml). Tris(triph chloride (1.04 g) is added and the mixture is stirred at room temperature for 20 hours. Purification by column chromatography gives the title compound (129 mg). 1H-NMR (CDCl3, 300 MHz): δ=9.79 (1H, s); 5.36 (1H, s); 1.05 (3H, s) 1.01 (3H, s); 0.95 (3H, d); 0.82 (3H, s); 0.80 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06884796B2 |
| Source dataset | uspto-grants-2005_04 |
| ORD ID | ord-226ce6a2bef74cf0afb6e22414beafb4 |
| Source note | uspto-grants-2005_04 |