Ethanol hydrochloride → HCID 69410776, compound

HRID 1816496Notes

Reaction equation

HRID 1816496 reaction equation
[Si]([O:8][C@H:9]1[CH2:31][CH2:30][C@@:29]2([CH3:32])[C@@H:11]([CH2:12][CH2:13][C:14]3[C:15]4[C@:25]([CH3:33])([CH2:26][CH2:27][C:28]=32)[C@@H:18]([C@H:19]([CH3:24])[CH2:20][CH2:21][CH2:22][NH2:23])[CH2:17][CH:16]=4)[C:10]1([CH3:35])[CH3:34])(C(C)(C)C)(C)C.Cl.[CH2:37]([OH:39])[CH3:38]>N1C=CC=CC=1.C(OC(=O)C)(=O)C>[CH3:35][C:10]1([CH3:34])[C@@H:9]([OH:8])[CH2:31][CH2:30][C@@:29]2([CH3:32])[C@H:11]1[CH2:12][CH2:13][C:14]1[C:15]3[C@:25]([CH3:33])([CH2:26][CH2:27][C:28]=12)[C@@H:18]([C@H:19]([CH3:24])[CH2:20][CH2:21][CH2:22][NH:23][C:37](=[O:39])[CH3:38])[CH2:17][CH:16]=3

Participants

5

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 69412184HCID 69412184, compound

Product 1

HCID 69410776HCID 69410776, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 7918Acetic AnhydrideSolvent

Procedure

3β-tert-Butyldimethylsilyloxy-4,4-dimethyl-24-amino-5α-chola-8,14-diene (0.50 g) is acetylated in a mixture of 20 ml of pyridine and 7 ml of acetic anhydride and hydrolysed with HCl/ethanol. After aqueous work-up and crystallisation from ethanol/water, the title compound (0.24 g) is isolated. Melting point: 219-221° C.

Workup

  1. customAfter aqueous work-up and crystallisation from ethanol/water

Sources & evidence

ORD record
ord-8bca2c67b7694c1ba9b05915043cb57e
Source dataset
uspto-grants-2005_04
Patent number
US06884796B2

Reaction notes

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