Idoxuridine → HCID 18667132, compound

Participants

Reaction Steps

2 g of 5-iodo-2′-deoxyuridine (5.65 mmole) was dissolved in 30 ml of pyridine, 5 ml of TEA and 2.16 g of MMTr-Cl (6.99 mmole) were sequentially added thereto, and stirred at room temperature for 4 hours. Then, pyridine was removed under a reduced pressure with a rotary evaporator, the residue was treated with a mixture of water and CH2Cl2, the CH2Cl2 layer was separated, dried under MgSO4, and then, CH2Cl2 was removed under a reduced pressure. The resulting residue was subjected to column chromatography (silica gel 60, 230˜400 meshes, Merck) to obtain the title compound as a pale yellow solid. The chromatography was conducted using a mixture of CH2Cl2 and methanol as an eluting solution whose mix ratio was gradually changed from 100:1 to 50:1 (v/v).

Provenance & Evidence