Hydrochloric Acid → HCID 22494325, compound

Participants

Reaction Steps

0.18 g of methyl 3-[4-methoxy-3-({[4-(trifluoromethyl)benzyl]amino}carbonyl)phenyl]-2propoxypropanoate was dissolved in 2 ml methanol, and 2 ml of 1 N sodium hydroxide was added, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was ice-cooled, neutralized with 1N hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and the solvent was evaporated, to give 0.15 g of 3-[4-methoxy-3-({[4-(trifluoromethyl)benzyl]amino}carbonyl)phenyl]-2-propoxypropanoic acid.

Provenance & Evidence